Relaxin Is a Key Mediator of Prostate Growth and Male Reproductive Tract Development
نویسندگان
چکیده
منابع مشابه
Pkd1 is required for male reproductive tract development
Reproductive tract abnormalities and male infertility have higher incidence in ADPKD patients than in general populations. In this work, we reveal that Pkd1, whose mutations account for 85% of ADPKD cases, is essential for male reproductive tract development. Disruption of Pkd1 caused multiple organ defects in the murine male reproductive tract. The earliest visible defect in the Pkd1(-/-) repr...
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Relaxin (RLN) belongs to a family of hormones structurally related to insulin and presents a broad spectrum of actions. Humans have three forms of RLN, encoded by three different genes (RLN1, RLN2 and RLN3), but nonprimate vertebrates have only two forms of relaxin (RLN1 and RLN3). RLN1 of these animals is encoded by Rln1, orthologous to the human RLN2 gene, and both genes, Rln1 and human RLN2,...
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A window of opportunity for maternal programming of neonatal development is open in the first few days of life as a consequence of nursing. Colostrum (first milk) supports neonatal development by providing a conduit for delivery of milk-borne bioactive factors, exemplified by relaxin, from mother to offspring as proposed in the lactocrine hypothesis. Relaxin, a prototypical milk-borne bioactive...
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Elucidating the role(s) of relaxin in women has been greatly hampered by its species specificity. Suitable experimental models of relaxin action in women are limited. We established a non-human primate model of early human pregnancy to study the effects of relaxin in vivo and used three well characterized in vitro models of human endometrial function for study of mechanisms involved. Results fr...
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Infertility is an uncommon manifestation of genitourinary tract tuberculosis. Anatomic obstruction by granulomas or distortion of the normal anatomy by fibrosis surrounding the reproductive tract structures is the commonest cause of infertility. The diagnosis is usually based on a suggestive history along with evidence of granulomatous infection on a tissue sample. The management depends on the...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2003
ISSN: 0023-6837,1530-0307
DOI: 10.1097/01.lab.0000079784.81186.b9